Urolithin A vs Fisetin: Which is Superior for Longevity?
Both Urolithin A and Fisetin are popular compounds in the world of longevity supplements, each offering unique mechanisms of action to promote healthy aging. Understanding the differences between them is essential when deciding which might be better for your needs.
Urolithin A is a postbiotic derived from the transformation of ellagitannins by gut bacteria. Its primary role is in promoting mitophagy, the process by which damaged mitochondria are removed and replaced. This function is essential for maintaining energy levels, muscle strength, and overall cellular health. Urolithin A has been tested in human clinical trials and shown to improve mitochondrial function and physical endurance.
Fisetin is a plant-derived flavonoid found in fruits like strawberries and apples. It acts as a senolytic, meaning it helps the body clear out senescent cells, which accumulate with age and contribute to inflammation and tissue dysfunction. While Fisetin has shown impressive results in animal models, human data is still limited.
Choosing between them depends on your goals. For mitochondrial energy and muscle function, Urolithin A is better supported by clinical evidence. If your focus is on cellular cleanup and reducing inflammation, Fisetin may be a helpful addition. In some cases, combining the two under proper guidance may offer a broader anti-aging benefit.
